The 24-year-old defender replaces the injured Reece Burke in the Hatters central defensive trio and is joined in the team by Issa Kaboré and former Villa midfielder Ross Barkley.
Pelly Ruddock Mpanzu and Tahith Chong drop to the Town bench as a result. Academy graduates Joe Johnson and Jayden Luker are also named among the substitutes.
Town: Kaminski; Kaboré, Doughty, Lockyer, Osho, Mengi; Nakamba, Barkley; Ogbene, Morris, Brown.
Subs: Krul, Woodrow, Adebayo, Chong, Mpanzu, Giles, Townsend, Johnson, Luker.
Villa: Martinez, Cash, Konsa, Luiz, McGinn, Watkins, Digne, Pau, Diaby, Zaniolo, Kamara.
Subs: Olsen, Carlos, Tielemans, Traore, Chambers, Lenglet, Bailey, Dendoncker, Iroegbunam.
Referee: John Brooks