Alex Palmer makes his Luton debut after arriving on an emergency loan deal yesterday with Harry Isted on the bench.
The two further changes are in attack - Danny Hylton and Cameron Jerome are brought into the starting eleven to support Elijah Adebayo.
Jordan Clark is back in the league matchday squad for the first time since the defeat against Sheffield United in January as the Hatters look to reclaim their place in the play-off positions with a positive result this afternoon.
Luton: Palmer; Bree, Lockyer, Burke, Naismith (C), Bell; Osho, Campbell; Hylton; Jerome, Adebayo.
Substitutes: Isted, Cornick, Berry, Snodgrass, Clark, Kioso, Lansbury.
Middlesbrough: Lumley; Dijksteel, Fry, McNair; Jones, Howson (C), Crooks, Tavernier, Taylor; Connolly, Balogun.
Substitutes: Daniels, Sporar, Peltier, Watmore, Bamba, Bola, Coburn.
Referee: Dean Whitestone