Saturday's meeting will be a real test for Nathan Jones' side against another play-off hopeful who are currently two points and two places below Luton in the Sky Bet Championship table.
The opposition:
After midweek success against Tottenham Hotspur in the FA Cup, confidence will be high in the Middlesbrough camp as they look to return to winning ways in the league.
It was defeat last time out for Chris Wilder's side against struggling Barnsley but prior to that, had picked up form in the league, with two wins and a draw from their last five matches.
Last time we met:
The Hatters scored three goals within five sensational minutes to stage a brilliant second half comeback to beat Middlesbrough at Kenilworth Road.
Josh Coburn had put the away side in front before Sonny Bradley, Elijah Adebayo and Harry Cornick all found the back of the net in quick succession.
Highlights from November's meeting can be found via our YouTube channel below...
Follow the action:
Supporters wishing to support the boys at the Riverside Stadium can purchase tickets on the day of the game from the away ticket office. More information - click HERE.
Saturday matches are not available domestically on iFollow, however, fans can tune into Simon Pitts’ match commentary via iFollow by purchasing an audio match pass for a single game, a month or for the season. Prices for all three options can be found HERE.
Ref watch
Referee: Dean Whitestone
Assistant Referees: Andrew Fox and Matthew McGrath
Fourth Official: Tom Nield
The man in the middle on Saturday afternoon is Dean Whitestone who most recently took charge of our 2-0 away defeat against Preston North End earlier this season.
Whitestone has officiated 26 games in total this season, handing out 74 yellow cards and one red in the process.