Reece Burke and Tahith Chong, who both came off on Saturday, don’t make it and the pair are replaced by Daiki Hashioka and Fred Onyedinma, who makes his first start since the 0-0 draw against Hull in May last year.
Jordan Clark returns to midfield in the place of Luke Berry, who drops to a youthful Town bench that includes 16-year-old, defender Christian Chigozie.
He started the season in Under-16s but has played regularly in the 18s and 21s, including the Premier League Cup matches.
Still in Year 11 at Chiltern Academy, next to the training ground, Christian will be sitting his GCSEs this summer and the Town had to ask for school's permission for him to miss classes to train with the first team last week.
Town: Kaminski, Kaboré, Hashioka, Mengi, Doughty, Onyedinma, Barkley, Mpanzu, Clark, Townsend, Morris.
Subs: Shea, Krul, Berry, Woodrow, Chong, Johnson, Chigozie, Nelson, Piesold.
Arsenal: Raya, Saliba, White, Partey, Gabriel, Odegaard, Smith Rowe, Trossard, Nelson, Havertz, Zinchenko.
Subs: Ramsdale, Jesus, Martinelli, Nketiah, Kiwior, Tomiyasu, Jorginho, Vieira, Rice.
Referee: Craig Pawson.