Harry Cornick makes his first start since November and he's joined by Elijah Adebayo up-front who returns after missing the last three league matches.
Kal Naismith captains the side once again as the Hatters go in search of a place in the play-off places should they win by three goals.
Town: Shea; Bree, Burke, Osho, Naismith (C), Bell; Mpanzu, Campbell, Lansbury; Cornick, Adebayo.
Substitutes: Steer, Potts, Hylton, Mendes Gomes, Lockyer, Kioso, Onyedinma.
Barnsley: Collins; Andersen (C), Helik, Kitching; Bassi, Styles, Gomes, Quina, Vita, Benson; Morris.
Substitutes: Walton, Williams, Iseka, Palmer, Hondermarck, Halme, Cole.
Referee: Andy Davies