Shortly before kick-off there was a late change as Elijah Adebayo picked up a knock in the warm-up. Cauley Woodrow took his place in the starting XI with Dan Potts coming in on the bench.
Reece Burke and Jordan Clark drop to a strong looking Hatters bench which also includes academy graduate Zack Nelson.
United manager Erik ten Hag, meanwhile, names an unchanged side that beat Aston Villa seven days ago.
Town: Kaminski; Ogbene, Doughty, Mengi, Osho, Bell; Lokonga, Barkley; Chong, Woodrow, Morris.
Subs: Krul, Berry, Potts, Kaboré, Burke, Mpanzu, Clark, Townend, Nelson.
Manchester United: Onana, Maguire, Fernandes, Rashford, Hojlund, Garnahco, Casemiro, Varane, Dalot, Shaw, Mainoo.
Subs: Bayindir, Lindleof, Amrabat, Eriksen, Diallo, Antony, Evans, McTominay, Forson.
Referee: David Coote