The manager revealed that both Reece Burke and Teden Mengi had not trained all week but the pair will be given enough time to feature at the Etihad Stadium.
“We’ve got seven centre halves at this club and not one has trained this week,” said Edwards. “Maybe we get one, maybe we get both, but maybe we don’t get either.
“Teden twice pushed through to help us win the game last week against Bournemouth and was in a lot of pain.”
The Hatters will also be without Issa Kaboré, who is ineligible against his parent club.
“He’ll be a big miss,” said the boss. “He’s had a great attitude and filled in a number of positions.”
Despite the Hatters injury problems, Edwards says his side will still approach the game with a positive mindset.
“It’s a challenge in normal circumstances,” said the manager. “But the we’ve trained like a team that will try and attack the game.
“We’ll have to ride our luck, we’ll need our players to play a 9, 9.5, 10, and Thomas will need to make some saves if we’re to get something – but we’re confident while recognising they are one of the best teams in world football.
“The players have responded well and trained well. If we get a result, given all the problems we’ve got, it’ll be one of the results of the century.”