Tom Lockyer has not recovered from a thigh injury which forced him off at half-time in Tuesday’s Carabao Cup tie with Gillingham, while Issa Kaboré drops to the bench.
Former Hammer Reece Burke starts and Pelly Ruddock Mpanzu is on the Hatters bench against his former side.
Among the substitutes are two Town Academy graduates, Joe Johnson and Aidan Francis-Clarke.
In Lockyer’s absence, striker Carlton Morris skippers the side.
Town: Kaminski; Doughty, Giles, Burke, Andersen, Bell; Nakamba, Chong, Barkley; Morris, Adebayo.
Subs: Krul, Ogbene, Berry, Woodrow, Kaboré, Mpanzu, Brown, Johnson, Francis-Clarke.
West Ham: Areola, Zouma, Coufal, Ward-Prowse, Antonio, Paqueta, Alvarez, Bowen, Benrahma, Aguerd, Emerson.
Subs: Fabianski, Cresswell, Fornals, Kudus, Cornet, Ings, Ogbonna, Kehrer, Mubama.
Referee: Paul Tierney.