Former Red Devils academy graduate Teden Mengi starts while Tahith Chong, who scored six days ago, takes his place on the bench.
There are two changes among the substitutes as Luke Berry returns from injury to replace Jayden Luker.
Town: Kaminski; Kaboré, Doughty, Lockyer, Mengi, Osho; Nakamba, Barkley, Townend; Obgene, Townsend, Morris.
Subs: Krul, Berry, Adebayo, Chong, Mpanzu, Clark, Brown, Giles, Nelson.
Manchester United: Onana, Lindelof, Maguire, Fernandes, Rashford, Hojlund, Eriksen, Reguilon, Garnacho, Dalot, McTominay.
Subs: Bayindir, Amrabat, Mount, Martial, Varane, Antony, Pellistri, Mainoo, Mejbri.
Referee: Graham Scott