Reece Burke comes back into defence after missing out against West Brom at the weekend, with Gabe Osho moving into midfield in place of the absent Pelly-Ruddock Mpanzu.
James Bree makes his 100th appearance for the Hatters, whilst Danny Hylton makes his second league start of the campaign and Harry Cornick returns in attack, supporting top scorer Elijah Adebayo.
Town: Steer; Bree, Lockyer, Burke, Naismith (C), Bell; Osho, Campbell; Cornick, Hylton, Adebayo.
Substitutes: Shea, Potts, Mendes Gomes, Kioso, Onyedinma, Muskwe, Jerome.
Stoke: Bursik; Wilmot, Moore, Harwood-Bellis, Tymon; Allen (C), Baker, Powell; Campbell, Philogene-Bidace; Maja.
Substitutes: Bonham, Smith, Clucas, Fletcher, Brown, Sawyers, Wright-Phillips.
Referee: John Busby