Sonny Bradley captains the side for the second match in a row following his clean sheet against West Bromwich Albion last weekend.
Elijah Adebayo and Carlton Morris lead the line together who have a combined eight goals this season.
You can watch the Hatters in action by purchasing a £10 iFollow match pass for today's match, due to the game falling outside of the 3pm broadcast window.
Luton Town: Horvath; Bree, Lockyer, Bradley (C), Potts, Bell; Lansbury, Campbell, Clark; Adebayo, Morris.
Substitutes: Isted, Cornick, Berry, Onyedinma, Freeman, Jerome, Doughty.
Queens Park Rangers: Dieng; Balogun, Dunne, Clarke-Salter, Paal; Iroegbunam, Field, Amos; Chair (C), Roberts; Dykes.
Substitutes: Archer, Kakay, Dickie, Johansen, Dozzell, Richards, Adomah.
Referee: Tony Harrington