Amari'i Bell returns from suspension to rejoin the defence, whilst Gabe Osho starts the first of his two matches on the sideline.
Elijah Adebayo was forced off through injury on Boxing Day and is amongst the substitutes, with Harry Cornick joining Carlton Morris up front.
Monday's hero Cauley Woodrow is on the bench, so too is former QPR midfielder Luke Freeman who scored the winning goal in the last meeting between the two teams.
Luton Town: Horvath; Bree, Lockyer, Potts (C), Bell, Doughty; Mpanzu, Campbell, Clark; Morris, Cornick
Substitutes: Isted, Berry, Woodrow, Adebayo, Watson, Freeman, Jerome.
Queens Park Rangers: Dieng; Laird, Dunne, Dickie, Paal; Field (C), Iroegbunam, Chair; Roberts, Shodipo; Dykes.
Substitutes: Archer, Kakay, Willock, Amos, Masterson, Richards, Adomah.
Referee: Gavin Ward