One is enforced, with Pelly-Ruddock Mpanzu having suffered an injury that forced him off in the 1-0 win at Sheffield United, meaning that Luke Berry - the man who replaced him in the first half at Bramall Lane - comes into the midfield from the start.
The other switch sees Alfie Doughty return to the starting XI after missing Saturday's victory through injury, with Fred Onyedinma moving to the bench.
The other changes from Saturday see Reece Burke and Louie Watson named among the substitutes.
The Hatters start the game in fourth place and on a run of just one defeat in ten league matches, the last four of which are unbeaten with three wins and a draw.
Bristol City start in 13th place, ten points adrift of the play-offs and 12 behing the Town, but they have an impressive record since the turn of the calendar year, with just one league defeat so far.
TOWN: Horvath; Drameh, Osho, Lockyer (C), Bell, Doughty; Nakamba, Berry, Campbell; Morris, Adebayo.
Subs: Shea, Woodrow, Lansbury, Burke, Watson, Onyedinma, Taylor.
ROBINS: O'Leary, Dasilva, Scott, Cornick, King, Mehmeti, Weimann (C), Pring, Sykes, Wells, Vyner.
Subs: Haikin (GK), Wilson, Tanner, Bell, Taylor-Clarke, Francois.
REFEREE: John Busby