Dan Potts captains the side upon his return from illness and Henri Lansbury is also back in the starting line-up, joining Jordan Clark and Allan Campbell in midfield.
Pelly-Ruddock Mpanzu returns to the matchday squad and is amongst the seven substitutes, with Harry Cornick and Cameron Jerome both attacking options from the bench.
Luton Town: Horvath; Bree, Lockyer, Potts (C), Bell; Doughty; Lansbury, Clark, Campbell; Morris, Adebayo.
Substitutes: Isted, Bradley, Cornick, Berry, Mpanzu, Freeman, Jerome.
Sunderland: Patterson; O'Nien, Batth, Wright, Cirkin; Evans (C), Neil; Diallo, Pritchard, Dajaku; Clarke.
Substitutes: Bass, Embleton, Simms, Roberts, Michut, Matete, Hume.
Referee: James Linington