After making a goalscoring return to the team in midweek, Fred Onyedinma starts on the left-hand-side, with Harry Cornick occupying the other flank.
Missing out through suspension, Kal Naismith is replaced by September's Diamond Player of the Month Luke Berry as the Hatters aim to extend their league unbeaten run to five matches.
Town: Sluga; Bree, Lockyer, Bradley (C), Bell; Rea, Berry, Clark; Cornick, Onyedinma; Adebayo.
Substitutes: Shea, Mendes Gomes, Burke, Mpanzu, Campbell, Muskwe, Jerome.
Hull: Ingram; Coyle, Bernard, Greaves, Elder; Smallwood (C), Docherty; Lewis-Potter, Honeyman, Wilks, Magennis.
Substitutes: Cartwright, Eaves, Emmanuel, Cannon, McLoughlin, Moncur, Williams.
Referee: John Busby