The boss has handed three competitive debuts to Ethan Horvath, Luke Freeman and number nine Carlton Morris - the latter who joins Elijah Adebayo up-front.
Captain Sonny Bradley leads a back five consisting of James Bree, Gabe Osho, Dan Potts and Amari'i Bell.
Allan Campbell and Jordan Clark join summer signing Freeman in midfield, whilst attackers Harry Cornick, Cauley Woodrow, Dion Pereira and Cameron Jerome are amongst the game-changers that the Welshman could call upon.
Reece Burke, Alfie Doughty and Luke Berry miss out through injury.
Luton Town: Horvath; Bree, Osho, Bradley (C), Potts, Bell; Campbell, Clark, Freeman; Morris, Adebayo.
Substitutes: Macey, Lockyer, Cornick, Woodrow, Lansbury, Pereira, Jerome.
Referee: Graham Scott