Reece Burke and Gabe Osho start in defence against the Latics once again as they did at Kenilworth Road ten days ago.
Louie Watson starts in midfield with Allan Campbell and captain Jordan Clark, whilst Cauley Woodrow starts in a more forward role alongside Elijah Adebayo - who scored his first goal since October at the weekend.
Top scorer Carlton Morris misses out after picking up a slight calf injury against West Brom.
Luton Town: Horvath; Doughty, Bree, Osho, Burke, Bell; Campbell, Watson, Clark (C); Woodrow, Adebayo.
Substitutes: Isted, Potts, Lockyer, Cornick, Berry, Mpanzu, Thorpe, Jerome, Pettit.
Referee: Matt Donohue