Peter Kioso makes his first league start for the Hatters, whilst there is a return to the eleven for Tom Lockyer as well.
Henri Lansbury – who played 45 minutes against West Brom – starts in midfield with Pelly-Ruddock Mpanzu, whilst Admiral Muskwe and Cameron Jerome also come in from the beginning to accompany Elijah Adebayo.
Town: Sluga; Bree, Kioso, Lockyer, Naismith (C), Bell; Lansbury, Mpanzu; Muskwe, Adebayo, Jerome.
Substitutes: Isted, Rea, Cornick, Lee, Mendes Gomes, Campbell, Osho
Barnsley: Collins; Sibbick, Helik, Kitching; Brittain, Styles, Palmer, Benson; Frieser, Woodrow (C), Oduor.
Substitutes: Walton, Williams, Moon, Halme, Miller, Adeboyejo, Cole.
Referee: Oliver Langford