Returning to the team after missing the last three games, the first through injury and the next two on the bench, is Elliot Lee.
The four-goal forward replaces Jorge Grant, who doesn’t feature in the matchday 18 due to a slight groin injury, with Lloyd Jones returning to the bench for the first time following his recent hernia operation.
The Hatters are seeking a third straight win in the league as they bid to cement their position in the play-off places, having moved up to sixth with Tuesday’s 4-1 win over Accrington Stanley at Kenilworth Road.
TOWN: Shea, Stacey, Pearson, Bradley, Justin, Rea ©, Mpanzu, Shinnie, Lee, Hylton, Collins. Subs: McCormack, Cornick, LuaLua, Jarvis, Jones, Sheehan, Isted.
DONS: McDonnell, Purrington, Oshilaja ©, Nightingale, Wagstaff, Hartigan, Appiah, Trotter, Hanson, Soares, McDonald. Subs: King (GK), Watson, Thomas, Pinnock, Egan, Burey, Pigott.
REFEREE: Andrew Davies