After netting his first goal of the season as a second-half substitute in the 2-2 draw at home to Charlton on Saturday, Harry Cornick returns to the starting line-up in place of midfielder Jorge Grant.
That means James Shea will be in goal, behind a back four of Jack Stacey, Matty Pearson, Sonny Bradley and Dan Potts. Captain Glen Rea will anchor a midfield also including Andrew Shinnie and Pelly-Ruddock Mpanzu, with Elliot Lee and Cornick in attack alongside James Collins, who also registered for the first time this season at the weekend.
The Town are looking to make it four matches unbeaten, with a first away victory of the season the aim as Jones and his side look to improve their 12th place in the table.
TOWN: Shea, Stacey, Pearson, Bradley, Potts, Rea, Mpanzu, Shinnie, Lee, Cornick, Collins. Subs: Justin, McCormack, Grant, LuaLua, Jarvis, Sheehan, Isted (GK)
OXFORD: Mitchell, Garbutt, Dickie, Nelson, Janson, Brannagan, Holmes, Whyte, Obika, Baptiste, McMahon. Subs: Shearer (GK), Smith, Carruthers, Ruffels, Mousinho, Henry, Mackie.
REFEREE: Michael Salisbury