Coming into the team for his first start of the season is midfielder Luke Berry, with Pelly-Ruddock Mpanzu dropping to the bench.
That means the Hatters, who arrive at Hillsborough on a 15-match unbeaten run in league and FA Cup, will have James Shea in goal behind a back four of Jack Stacey, Matty Pearson, Sonny Bradley and James Justin.
Alan McCormack will anchor midfield alongside Berry, Andrew Shinnie and Elliot Lee, with James Collins and Danny Hylton up front.
The hosts are a division above the Town, but their current position of 16th in the Championship means they are ten places above Jones' side in the pyramid.
TOWN: Shea, Stacey, Pearson, Bradley (c), Justin, McCormack, Berry, Shinnie, Lee, Collins, Hylton. Subs: Mpanzu, Grant, LuaLua, Jarvis, Jones, Sheehan, Isted.
OWLS: Dawson, Palmer, Fox, Fletcher, Bannan, Lees, Matias, Reach, Boyd, Hutchinson, Hector. Subs: Wildsmith, Pelupessy, Winnall, Thornley, Nuhiu, Baker, Shaw
REFEREE: Robert Jones