Wednesday night's second goalscorer Kazenga LuaLua starts for the first time since the 3-0 loss against Hull in September.
Goal providing substitute Luke Bolton is also in from the kick-off after an impressive performance from the bench against Fulham, as does Callum McManaman.
James Bree, Harry Cornick and James Collins drop to the bench as the 18th-placed Hatters look to return to winning ways against their opponents, who start the afternoon five points better off in 11th.
TOWN: Shea, Bolton, Pearson, Cranie, Bradley, Potts, Tunnicliffe, Mpanzu, Brown, McManaman, LuaLua.
Subs: Shinnie, Sluga, Cornick, Collins, Bree, Jones, Butterfield.
BIRMINGHAM:Camp, Colin, Dean, Roberts, Pedersen, Sunjic, Bellingham, Crowley, Villalba, Mrabti, Jutkiewicz
Subs: Trueman, Harding, Clarke-Salter, Davis, Bailey, Maghoma, Gimenez
Referee: Dean Whitestone