Captain Sonny Bradley returns to the starting line-up as Lloyd Jones drops to the bench.
After missing the Reading game through injury, Izzy Brown also makes an immediate return to face the club where he spent last season on loan. Andrew Shinnie also returns for his first start since Derby in October, alongside Pelly-Ruddock Mpanzu.
The trio replace Jacob Butterfield, Callum McManaman and Martin Cranie respectively.
After coming off the bench against Reading, James Bree starts at right-back in place of Luke Bolton as the Hatters go in search of three points that could see them move up to 19th place.
TOWN: Shea, Bree, Pearson, Bradley (c), Potts, Tunnicliffe, Shinnie, Mpanzu, Brown, Cornick, Collins.
Subs: Sluga, McManaman, Bolton, Galloway, LuaLua, Jones, Butterfield
LEEDS: Casilla, Ayling (c), White, Bamford, Roberts, Dallas, Hernandez, Harrison, Phillips, Berardi, Klich
Subs: Meslier, Douglas, Cooper, Alioski, Costa, Gotts, Clarke
REFEREE: John Brooks