Izzy Brown makes his first start since he suffered an injury against Brentford in November ahead of Kazenga LuaLua, who drops to the bench.
After coming on during last weekend's loss to West Bromwich Albion, Cameron Carter-Vickers makes his first start for the club in place of Donervon Daniels.
The Hatters could move to within four points of safety with a victory against Neil Harris' Cardiff, whilst the away side could rise up to 8th place.
TOWN: Sluga, Bree, Carter-Vickers, Pearson, Potts, Tunnicliffe, Mpanzu, Rea, Cornick, Brown, Collins (C)
Substitutes: Shea, McManaman, Berry, Shinnie, Moncur, LuaLua, Daniels
CARDIFF: Smithies, Richards, Morrison (C), Nelson, Bennett, Pack, Vaulks, Paterson, Adomah, Murphy, Tomlin
Substitutes: Etheridge, Flint, Bacuna, Glatzel, Whyte, Ward, Hoilett
REFEREE: James Linigton