Martin Cranie – who was on the bench against Charlton Athletic on Saturday – replaces James Bree, who drops to the substitutes.
James Collins leads the line once again and captains the side with Sonny Bradley still sidelined through injury.
Town will be look to move to within three points of safety with a win tonight, whilst Brentford could move up to third in the Championship.
TOWN: Sluga, Cranie, Pearson, Carter-Vickers, Potts, Tunnicliffe, Rea, Mpanzu, Berry, Cornick, Collins (C)
Substitutes: Stech, McManaman, Hylton, Shinnie, Moncur, Bolton, Bree
BRENTFORD: Raya, Roerslev, Dalsgaard (C), Pinnock, Henry, Norgaard, Dasilva, Baptiste, Mbeumo, Benrahma, Watkins
Substitutes: Daniels, Valencia, Marcondes, Dervisoglu, Fosu, Zamburek, Racic