Mpanzu - who signed permanently for the club on this day in 2014 - starts alongside Jordan Clark and Allan Campbell as the boss names a strong line-up for the visit of the Mariners.
Gabe Osho starts for the third match in succession after being forced off against Wigan Athletic last weekend, whilst Dan Potts captains the side with Tom Lockyer in-between the pair.
17-year-old Zack Nelson is amongst the nine substitutes after impressing during the FA Youth Cup victory against QPR U18s 10 days ago.
New signing Cody Drameh is ineligible for today's fixture having played for Leeds United in the competition already this season.
Luton Town: Horvath; Doughty, Osho, Lockyer, Potts (C), Bell; Campbell, Clark, Mpanzu; Cornick, Adebayo.
Substitutes: Isted, Berry, Morris, Woodrow, Burke, Watson, Onyedinma, Thorpe, Nelson.
INTERNATIONAL BROADCAST
Supporters based overseas should be aware that today's game is available to watch live on TV in the following countries: