The suspended Tom Lockyer is replaced by Alfie Doughty who returns to the starting line-up after coming off the bench against Burnley last weekend.
Fred Onyedinma replaces the number 45 and returns to the substitutes having missed out in the last match.
Midfielder Pelly-Ruddock Mpanzu captains the side as the Hatters look to get back to winning ways.
Luton Town: Horvath; Drameh, Burke, Osho, Bell, Doughty; Nakamba, Mpanzu, Clark; Morris, Adebayo.
Substitutes: Shea, Potts, Berry, Woodrow, Campbell, Onyedinma, Taylor.
Birmingham City: Ruddy (C); Colin, Long, Dean, Longelo; Hall, Hannibal, Gardner, Chong; Hogan, Jutkiewicz.
Substitutes: Etheridge, Friend, Roberts, Bacuna, Graham, James, Chang.
Referee: David Webb