Coming into the team from kick-off for the first time since the draw at Preston last month is Fred Onyedinma, who replaces Alfie Doughty.
Pelly-Ruddock Mpanzu also returns to the side after featuring in last week's win over Swansea from the bench. The 28-year-old appears in midfield for the 360th time in a Luton shirt in place of Jordan Clark, who like Doughty, misses out through injury.
The fifth-placed Hatters will be looking to close the gap on the hosts, who sit second in the table, to seven points and could move up a place to fourth if they make it seven away league games without defeat.
TOWN: Horvath; Drameh, Osho, Lockyer (C), Bell, Onyedinma; Nakamba, Mpanzu, Campbell; Morris, Adebayo.
Subs: Shea, Bradley, Berry, Woodrow, Lansbury, Muskwe, Taylor.
BLADES: Foderingham, Fleck, Berge, McBurnie, Egan (C), Lowe, Ahmedhodzic, Norwood, Robinson, Bogle, Ndiaye.
Subs: Davies, Baldock, Sharp, Basham, Doyle, Clark, McAtee.
REFEREE: Leigh Doughty