Osho makes his first appearance since the 1-1 draw against Crystal Palace while it’s Lokonga is back in the XI having limped off at half-time in the defeat a Liverpool in February.
Mengi slots back in after a week’s rest – his last appearance since the win over Bournemouth.
Issa Kaboré, who was unavailable to feature against his parent club Manchester City last weekend, also returns.
It means Luke Berry, Fred Onyedinma, Daiki Hashioka and Andros Townsend all drop to a strong Town bench.
For Brentford there is no Ivan Toney among their squad.
Town: Kaminski; Kaboré, Doughty, Osho, Mengi, Burke; Lokonga, Barkley, Clark, Chong, Morris.
Subs: Shea, Krul, Berry, Woodrow, Mpanzu, Hashioka, Townsend, Onyedinma, Johnson.
Brentford: Flekken, Pinnock, Jensen, Wissa, Reguilon, Mbeumo, Ajer, Collins, Lewis-Potter, Damsgaard, Janelt.
Subs: Strahoska, Norgaard, Maupay, Schade, Zanka, Ghoddos, Onyeka, Roerslev, Yarmoliuk.
Referee: Jarred Gillett