The Welshman has made one change as Gabe Osho comes in to start after scoring in midweek, replacing Reece Burke in defence who misses out through injury.
Sonny Bradley returns to the bench, as does Harry Cornick who features in the matchday squad for the first time since the Carabao Cup defeat against Newport County.
Fred Onyedinma can be called upon once again after making a positive impact versus Cardiff City in midweek as the Hatters continue their search for a first home win of the season.
Luton Town: Horvath; Bree, Osho, Lockyer, Potts (C), Bell; Campbell, Clark, Freeman; Morris, Adebayo.
Substitutes: Macey, Bradley, Cornick, Berry, Woodrow, Onyedinma, Jerome.
Wigan Athletic: Amos; Kerr, Whatmough, Tilt; Nyambe, Naylor, Power (C), McClean; Magennis, Lang, Keane.
Substitutes: Jones, Shinnie, Broadhead, Bennett, Fletcher, Edmonds-Green, Aasgaard
Referee: Chris Kavanagh