The only change from the New Year's Day victory against Huddersfield Town comes in midfield, with Jordan Clark replacing Louie Watson after recovering from a knock.
Tom Lockyer missed last week's FA Cup match against Wigan Athletic but returns to the starting eleven.
Town's leading scorer Carlton Morris is joined by Elijah Adebayo up front as manager Rob Edwards goes in search of a fourth consecutive league victory.
Luton Town: Horvath; Doughty, Bree, Lockyer, Potts (C), Bell; Mpanzu, Campbell, Clark; Morris, Adebayo.
Substitutes: Isted, Cornick, Woodrow, Burke, Watson, Osho, Jerome.
West Brom: Palmer; Furlong, O'Shea (C), Pieters, Townsend; Molumby, Yokuslu; Wallace, Swift, Phillips; Dike.
Substitutes: Button, Ajayi, Rogic, Livermore, Diangana, Reach, Gardner-Hickman.
Referee: Josh Smith