Alfie Doughty misses out through an injury he sustained against Coventry City at the weekend, replaced by Fred Onyedinma who makes his second start for the club since October.
Dan Potts is on the bench after missing the last few matches, replacing the number 45 who is unavailable.
Striker Joe Taylor made his Luton Town debut on Saturday and is amongst the substitutes once again, so too is Luke Berry who scored a brace against this evening's opponents in March last year.
Luton Town: Horvath; Onyedinma, Burke, Lockyer (C), Osho, Bell; Mpanzu, Clark, Nakamba; Morris, Adebayo
Substitutes: Shea, Potts, Berry, Woodrow, Lansbury, Campbell, Taylor.
Referee: Josh Smith