Harry Cornick replaces Carlton Morris up-front to partner Elijah Adebayo.
Luke Freeman keeps his place in midfield after impressing against Birmingham City on his debut, alongside Allan Campbell and last week's Man of the Match - Jordan Clark.
Luke Berry and Reece Burke are fit enough for the bench, whilst Alfie Doughty remains out through injury.
Luton Town: Horvath; Bree, Osho, Bradley (C), Potts, Bell; Campbell, Clark, Freeman; Cornick, Adebayo.
Substitutes: Macey, Lockyer, Berry, Morris, Woodrow, Lansbury, Burke.
Referee: Darren Bond
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