Allan Campbell netted the Town's first goal in the 2-0 win Swansea back in August, and he starts a league game for the first time since the win over Stoke City a month ago.
The Scotland international will line up in midfield alongside Marvelous Nakamba and Jordan Clark, with Pelly-Ruddock Mpanzu named among the substitutes in the only switch from Tuesday night's 2-2 draw with Millwall.
Elijah Adebayo, who scored the first goal to spark the midweek comeback from 2-0 down, moves closer to joining the 100-appearance club as he wears a Luton shirt for the 97th time today, while the scorer of the late equaliser, Luke Berry, who recently clocked up 150 appearances as a Hatter, is on the bench.
The Hatters start in sixth place in the table, occupying the final play-off spot, while the visitors from south Wales are in 15th position, 11 points behind Town with both clubs having played 34 matches.
Luton Town: Horvath; Drameh, Lockyer, Osho, Bell, Doughty; Nakamba, Campbell, Clark; Morris, Adebayo.
Substitutes: Shea, Bradley, Berry, Woodrow, Mpanzu, Onyedinma, Taylor.
Swansea City: Fisher; Manning, Fulton, Cabango, Allen (C), Piroe, Cundle, Latibeaudiere, Wood, Sorinola, Cooper.
Substitutes: Darling, Paterson, Whittaker, Cullen, Naughton, Sondergaard, Walsh.
Referee: Dean Whitestone