Kazenga LuaLua – who will be making his fourth start for the Town – comes in for the suspended Danny Hylton, whilst Luke Berry replaces Alan McCormack.
James Shea starts in goal with a back four in front of him that haven't conceded in the competition thus far – with Jack Stacey at right back, Matty Pearson and Sonny Bradley as the centre backs, and James Justin at left back.
Going off Town sides from earlier on this campaign, Pelly-Ruddock Mpanzu will most likely start in the holding midfield role, with Berry and Andrew Shinnie playing in the central roles, whilst Elliot Lee will play at the point of the diamond.
LuaLua and James Collins will lead the line, as the Hatters look to make it to the fourth round – with an away tie at current FA Cup holders Chelsea awaiting the victors of tonight's game.
Town team: Shea, Stacey, Pearson, Bradley, Justin, Mpanzu, Shinnie, Berry, Lee, Collins, LuaLua.
On the bench: Isted, Potts, McCormack, Jarvis, Jones, Sheehan, Neufville.