Admiral Muskwe makes his fourth league start of the season after impressing from the bench against Blackpool and Pelly-Ruddock Mpanzu also returns to the starting line-up in place of Henri Lansbury.
James Shea keeps his place in goal while Simon Sluga is amongst the substitutes after returning from illness.
Luton: Shea; Bree, Burke, Bradley (C), Naismith, Bell; Campbell, Mpanzu, Clark; Muskwe, Adebayo.
Substitutes: Sluga, Hylton, Mendes Gomes, Lansbury, Onyedinma, Osho, Jerome.
Fulham: Rodak; Tete, Adarabioyo, Ream, Bryan; Seri, Cairney; Wilson, De Cordova-Reid, Kebano; Mitrovic.
Substitutes: Gazzaniga, Hector, Odoi, Muniz, Onomah, Carvalho, Robinson.
Referee: Thomas Bramall