After Rhys Norrington-Davies was today recalled by parent club Sheffield United, Dan Potts slots in at left-back.
James Bree starts his first Championship game since the defeat to Swansea City in December, whilst Kazenga LuaLua is included in the starting eleven for the second time in the league this season.
He and Harry Cornick will provide support to striker James Collins, who is Town’s top scorer this season with nine goals in all competitions.
Peter Kioso is amongst the substitutes after the Hatters opted to recall him from his loan spell with Sky Bet League Two side Bolton Wanderers.
Town: Sluga; Bree, Lockyer, Bradley (C), Potts; Rea, Mpanzu, Dewsbury-Hall; Cornick, LuaLua, Collins.
Substitutes: Shea, Tunnicliffe, Berry, Hylton, Moncur, Clark, Kioso, Galloway, Nombe.
QPR: Dieng; Kane, Barbet, Cameron (C), Dickie; Ball, Carroll, Chair, Osayi-Samuel; Dykes, Austin.
Substitutes: Lumley, Bonne, Thomas, Willock, Masterson, Hamalalinen, Bettache, Kelman, Adomah
Referee: Andy Woolmer