Sam Beckwith makes his senior debut for the club at left-back after featuring for the development squad at the weekend.
Cameron Jerome makes his competitive debut for the Hatters, whilst there are first starts in a Luton shirt for Henri Lansbury, Carlos Mendes Gomes and Admiral Muskwe.
Tom Lockyer returns from an injury lay-off and partners Gabe Osho in defence, whilst there are inclusions for youngsters Avan Jones and Ed McJannet amongst the substitutes.
Town: Shea; Kioso, Lockyer, Osho, Beckwith; Rea (C), Lansbury; Muskwe, Lee, Mendes Gomes; Jerome
Substitutes: Isted, Bree, Cornick, Pereira, Campbell, Jones, McJannet.
Stevenage: Anang; Wildin, Vancooten, Cuthbert, Coker; Osborne, Taylor, Reeves, Carter; Reid, List.
Substitutes: Bastien, Prosser, Norris, Lines, Smith, Marshall, Williams.
Referee: Gavin Ward