George Moncur starts for the first time since defeat versus Norwich City in March, coming in for Dan Potts to enable a change of formation.
Harry Cornick and Pelly-Ruddock Mpanzu are also included in the starting eleven, making up the second and third changes, as the Hatters aim to end their campaign on a high in W12.
Town: Sluga; Bree, Pearson, Bradley (C), Naismith; Rea, Mpanzu, Dewsbury-Hall; Cornick, Moncur; Adebayo.
Substitutes: Shea, Cranie, Potts, Tunnicliffe, Berry, Collins, LuaLua, Morrell, Pereira.
Queens Park Rangers: Dieng; Dickie, De Wijs, Barbet; Kakay, Chair, Willock, Johansen, Wallace; Dykes, Austin.
Substitutes: Walsh, Bonne, Field, Thomas, Cameron, Carroll, Hamalainen, Bettache, Adomah.
Referee: Tony Harrington