Simon Sluga is back between the sticks after serving his isolation period, while Amari'i Bell returns to defence.
Glen Rea is back in the side for the first time since the away defeat against Preston North End in October, alongside Pelly-Ruddock Mpanzu and Jordan Clark in midfield - the latter of which came off the bench versus Nottingham Forest.
Harry Cornick is the fifth change partnering Elijah Adebayo up front as the Hatters go in search of a first win in four matches.
Town: Sluga; Bree, Lockyer, Bradley (C), Naismith, Bell; Rea, Mpanzu, Clark; Cornick, Adebayo.
Substitutes: Shea, Hylton, Burke, Campbell, Lansbury, Onyedinma, Jerome.
Cardiff: Smithies; McGuinness, Morrison (C), Nelson; Ng, Pack, Ralls, Giles; Colwill; Collins, Moore.
Substitutes: Phillips, Flint, Vaulks, Bacuna, Harris, Brown, Davies
Referee: Oliver Langford