Following the 1-0 victory away at Norwich in midweek, captain Sonny Bradley returns to the starting line-up as Dan Potts drops to the bench.
Alfie Doughty keeps his place in the team after making his competitive debut on Tuesday night, whilst Luke Freeman comes into midfield.
Elijah Adebayo joins Carlton Morris up front, with Harry Cornick starting on the bench along with fellow forward Cameron Jerome.
Henri Lansbury misses out on the matchday squad through illness as Louie Watson is brought in to replace him.
Luton Town: Horvath; Bree, Lockyer, Bradley (C), Bell, Doughty; Campbell, Clark, Freeman; Morris, Adebayo.
Substitutes: Isted, Potts, Cornick, Berry, Watson, Osho, Jerome.
Referee: Robert Madley