Jordan Clark makes his first league start of the season as Elliot Lee begins amongst the substitutes.
Glen Rea is back after missing out last weekend and comes straight back into the starting line-up, with Ryan Tunnicliffe on the bench.
Centre-back Matty Pearson makes his 100th appearance in a Luton Town shirt this afternoon alongside captain Sonny Bradley.
Congratulations Matty and come on you Hatters!
Town: Sluga, Cranie, Pearson, Bradley (C), Norrington-Davies; Rea, Berry, Mpanzu; Cornick, Clark, Collins.
Substitutes: Shea, Tunnicliffe, Hylton, Lee, Moncur, Kioso, LuaLua.
Wycombe: Allsop, Grimmer, Stewart, Charles Jacobson (C); Wheeler, Adeniran, Freeman, Horgan, Thompson, Samuel
Substitutes: Stockdale, Bloomfield, Kashket, Phillips, Onyedinma, McCarthy, Parker
Referee: Graham Scott