After making a vital contribution from the bench against Wycombe Wanderers last weekend, Kiernan Dewsbury-Hall and Kazenga LuaLua both start this afternoon.
Dan Potts is back in the matchday squad for the first time since he was injured during the home defeat to Swansea City over a month ago.
Youngster and ex-Watford man Dion Pereira is amongst the substitutes as the Hatters welcome their main rivals to Kenilworth Road for the first time in 15 years.
Town: Sluga; Bree, Pearson, Bradley (C), Naismith; Berry, Mpanzu, Dewsbury-Hall; Clark, LuaLua, Adebayo.
Substitutes: Shea, Cranie, Potts, Tunnicliffe, Moncur, Rea, Collins, Morrell, Pereira
Watford: Bachmann; Femenia, Troost-Ekong, Sierralta; Masina; Sanchez, Hughes (C), Zinckernagel, Sarr, Sema; Pedro
Substitutes: Foster, Cleverley, Cathcart, Gosling, Lazaar, Gray, Success, Kabasele, Hungbo
Referee: Gavin Ward