Harry Cornick starts for the first time since the Stoke match last month after suffering an injury.
George Moncur makes his first league start of the campaign in midfield alongside Ryan Tunnicliffe, who makes his second league start following the match against Watford.
Joe Morrell also lines-up from the start in the middle, which is also a second start for him as a Hatter.
After coming on as a half-time substitute on Saturday, Luke Berry begins, as does James Collins, who came on against Brentford as well.
Right-back James Bree is back amongst the substitutes, as is Sam Nombe, who could make his Town debut this evening.
Town: Sluga, Cranie, Pearson, Bradley (C); Rea, Tunnicliffe, Berry, Morrell, Moncur; Cornick, Collins.
Substitutes: Shea, Lee, Lockyer, Mpanzu, LuaLua, Bree, Nombe
Rotherham: Blackman, Harding, Ihiekwe, A. MacDonald, Mattock; Jozefzoon, Wiles, Lindsay, Barlaser, Miller, Smith.
Substitutes: Johansson, Wood, Crooks, Sadlier, Vassell, Hirst, Ladapo.
Referee: Andy Madley