Dan Potts makes his first start for the Hatters since he suffered an injury in the first half of the Swansea City defeat back in March.
Ryan Tunnicliffe starts in midfield alongside Glen Rea who scored in the 1-1 draw versus Middlesbrough at the weekend as Town look to extend their five-match unbeaten run in the Sky Bet Championship.
Town: Sluga; Bree, Pearson, Bradley (C), Potts, Naismith; Tunnicliffe, Rea, Dewsbury-Hall; Collins, Adebayo
Substitutes: Shea, Cranie, Cornick, Moncur, Mpanzu, LuaLua, Nombe, Morrell, Pereira
Rotherham: Blackman, Olosunde, Harding, Wood (C), Ihiekwe, Giles, Barlaser, Wiles, Wing, Crooks; Smith.
Substitutes: Johansson, Mattock, A.MacDonald, S.MacDonald, Lindsay, Sadlier, Jozefzoon, Ogbene, Ladapo.
Referee: David Webb