Dan Potts starts at left-back, making his 150th appearance for the Hatters after his debut five years ago against Bristol City in the League Cup.
Another landmark for the Town – Pelly-Ruddock Mpanzu will mark his 250th appearance in a Luton shirt. His first game for the club came in the November 2013, in an FA Trophy fixture against Staines.
The nine substitutes also remain the same as they were on Friday night against Huddersfield Town, as the Hatters aim to move out of the relegation zone for the first time since December.
TOWN: Sluga, Bree, Carter-Vickers, Bradley (C), Potts, Mpanzu, Shinnie, Berry, Lee; Cornick, Collins.
Substitutes: Shea, Cranie, Tunnicliffe, McManaman, Hylton, Moncur, LuaLua, Butterfield, Kioso.
QPR: Lumley, Rangel, Manning, Barbet (C), Cameron, Kakay, Ball, Amos, Eze; Chair, Osayi-Samuel
Substitutes: Kelly, Kane, Wallace, Shodipo, Oteh, Masterson, Bettache, Gubbins, Clarke
Referee: Stephen Martin