George Moncur replaces Glen Rea, the only switch from Saturday’s 1-0 victory against AFC Bournemouth
Despite being forced off with an injury during the first half at the weekend, Tom Lockyer is fit and in the starting eleven.
Luton: Sluga, Bree, Lockyer, Bradley (C), Potts; Mpanzu, Berry, Dewsbury-Hall; Moncur, Cornick, Collins.
Substitutes: Shea, Tunnicliffe, Pearson, Hylton, Rea, Clark, Naismith, LuaLua, Nombe.
Brentford: Raya; Dalsgaard (C), Pinnock, Sorensen, Henry; Janelt, Jensen, Ghoddos; Canos, Mbeumo, Toney
Substitutes: Daniels, Goode, Forss, Dervisoglu, Roerslev, Fosu, Stevens, Gilbert
Referee: Stephen Martin