Town will be hoping to progress into the fourth round for the first time since 2007.
Former Foxes defender Alan Sheehan captains the Hatters and hopes to add to his goal in the last round when he scored in Luton’s 3-0 victory over Cardiff City.
Elliot Lee and Lloyd Jones both netted in the first round of this competition against Ipswich Town and are back in the starting line-up tonight.
Luke Bolton is the only player still in the starting eleven from Saturday as the Hatters welcome home James Justin, who makes his competitive debut in a Leicester City shirt.
TOWN: Shea, Bolton, Jones, Sheehan (C), Potts, McManaman, Butterfield, Berry, Mpanzu, Moncur, Lee. Subs: Tunnicliffe, Pearson, Sluga (GK), Cornick, Brown, LuaLua, Bree
LEICESTER: Ward, Justin, Morgan (C), Evans, Fuchs, Albrighton, Tielemans, Ndidi, Praet, Gray, Perez. Subs: Schmeichel, Vardy, Iheanacho, Barnes, Amartey, Choudhury, Pereira.