Fred Onyedinma is back in the starting line-up and after serving his one-match suspension, Henri Lansbury comes back into the eleven alongside Allan Campbell who made his long-awaited return from injury in the last match against Stoke City.
The third change is in defence - with Tom Lockyer returning to play next to captain Sonny Bradley as the Hatters aim to win away at QPR for the first time since 1984.
Town: Sluga; Bree, Lockyer, Bradley (C), Naismith; Lansbury, Campbell, Mpanzu; Cornick, Onyedinma; Adebayo.
Substitutes: Shea, Hylton, Clark, Muskwe, Bell, Osho, Jerome
QPR: Dieng, Barbet, Dunne, Dickie; Wallace, Johansen, Dozzell; Adomah; Chair, Willock; Austin.
Substitutes: Kakay, Amos, Ball, Archer, Thomas, Field, Duke-McKenna.
Referee: Matt Donohue