Tonight marks a special milestone for James Shea who makes his 100th Luton appearance after joining the club back in 2017.
There are two changes to the backline in front of him, with Peter Kioso and Dan Potts drafted in to defence, the latter of whom captains the side in the absence of Kal Naismith.
Luke Berry starts in midfield with Pelly-Ruddock Mpanzu out with an injury and in attack, Harry Cornick partners Elijah Adebayo.
Luton: Shea; Bree, Kioso, Burke, Potts (C), Bell; Berry, Campbell; Clark; Cornick, Adebayo.
Substitutes: Isted, Hylton, Mendes Gomes, Lansbury, Onyedinma, Muskwe, Thorpe.
Preston North End: Iversen; Van den berg, Diaby, Hughes; Potts, Whiteman, McCann, Johnson; Browne (C); Riis, Archer.
Substitutes: Ripley, Bauer, Evans, Rafferty, Maguire, Sinclair, Murphy.
Referee: Stephen Martin